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KMID : 0387420080190020065
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Korean Society of Oriental Neuropsychiatry
2008 Volume.19 No. 2 p.65 ~ p.75
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The Effects of KakamBoyangHwanoh-Tang(KBHT) and PalMihapChongMung-Tang(PMCMT) on Protecting Microglia and Inhibiting Acetylcholinesterase and Oxidants
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Kim Hyun-Ju
Lee Sang-Ryong
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Abstract
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Objective : This experiment was designed to investigate the effect of the KBHT and PMCMT extract on protecting microglia and inhibiting acetylcholinesterase and oxidants.
Method : The effects of the KBHT and PMCMT extract on cell death of BV2 microglial cell line treated by ; expression of NO, ROS in BV2 microglial cell line treated by lipopolysaccharide(LPS) ; AChE activity in PC-12 cell treated by NGF were investigated, respectively.
Result : The KBHT and PMCMT extract significantly increased cell viability in BV2 microglial cell line treated with . The KBHT and PMCMT extract suppressed the NO and ROS production in BV2 microglial cell line treated by LPS. The KBHT and PMCMT extract groups also showed inhibition of AChE activity in PC-12 cell line.
Conclusion : According to the above result, it is suggested that the KBHT and PMCMT extract might be usefully applied for prevention and treatment of Alzheimer’ s disease.
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KEYWORD
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KakamBoyangHwanoh-Tang(KBHT), PalMihapChongMung-Tang(PMCMT), Microglia, acetylcholinesterase, ROS
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